Dimethylformamide → 4-Chloro-7-nitroquinazoline

HRID 237316

Reaktionsgleichung

Reaktionsgleichung von HRID 237316
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=O)[NH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].CN(C=O)C.S(Cl)([Cl:22])=O>>[Cl:22][C:8]1[C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[N:11]=[CH:10][N:9]=1

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 862228007-Nitroquinazolin-4(3H)-one

Produkt 1

HCID 8306804-Chloro-7-nitroquinazoline

Versuchsvorschrift

To a solution of 7-nitroquinazolin-4(3H)-one (2.0 g, 10.5 mmol) in 40 ml thionyl chloride was added 0.8 ml of DMF and the mixture was heated at reflux overnight then evaporated to dryness to provide crude 4-chloro-7-nitroquinazoline.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customthen evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f0f7d6401cd4487e98e4fe40bbd46dba
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642582B2

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