Water → Imidazo(1,2-a)pyrazine-3-carbaldehyde

HRID 2374139Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2374139
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.P(Cl)(Cl)(Cl)=O.O.CN([CH:19]=[O:20])C>>[N:1]1[CH:2]=[C:3]([CH:19]=[O:20])[N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12

Komponenten

5

Edukt 4

HCID 962WaterHCID 6228Dimethylformamide2×HCID 24813Phosphorus oxychlorideHCID 2771670Imidazo(1,2-a)pyrazine

Produkt 1

HCID 13634591Imidazo(1,2-a)pyrazine-3-carbaldehyde

Versuchsvorschrift

Imidazo[1,2-a]-pyrazine (0.30 g, 2.5 mmol) was dissolved in anhydrous DMF (10.0 mL) and added to a preformed solution of phosphorous oxychloride (0.26 mL, 2.8 mmol) in anhydrous DMF (10.0 mL). The solution was allowed to stir 72 h under nitrogen at RT. The solution was then poured into water (100 mL) and residual organics extracted with diethyl ether (3×30 mL). The remaining aqueous portion was concentrated to dryness under a nitrogen stream to yield the title compound (0.050 g). MS (ESI+) for m/z 148 (M+H)+.

Aufarbeitung

  1. extractionresidual organics extracted with diethyl ether (3×30 mL)
  2. concentrationThe remaining aqueous portion was concentrated to dryness under a nitrogen stream

Quellen und Nachweise

ORD-Eintrag
ord-827e7449345b4f2d936b529a177db2e8
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07462600B2

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