Water → (S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

HRID 237500Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 237500
Br[CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5].[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([OH:15])=[CH:10][C:9]=1[CH3:16].C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5])=[CH:10][C:9]=1[CH3:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 819704-Bromo-3,5-dimethylphenolHCID 10986449(S)-(+)-3-Bromo-2-methyl-1-propanol

Produkt 1

HCID 86697161(S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

(S)-3-Bromo-2-methyl-1-propanol (150 mg), 4-bromo-3,5-dimethylphenol (98.5 mg) and potassium carbonate are stirred in 5 mL of acetonitrile at 80° C. for 4 h. The reaction mixture is cooled to room temperature, water is added and the reaction mixture is extracted with diethyl ether. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give a solid, used in the next step without further purification. Yield: 130 mg.

Aufarbeitung

  1. extractionthe reaction mixture is extracted with diethyl ether
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum
  5. customto give a solid
  6. customused in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-f9e343ff26554e5aa368257b928847e3
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642585B2

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