4-Isobutyl-3-nitro quinoline → 4-Isobutyl 3-amino quinoline

HRID 23766

Reaktionsgleichung

Reaktionsgleichung von HRID 23766
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[N+:15]([O-])=O)[CH:2]([CH3:4])[CH3:3]>C1(C)C=CC=CC=1.[Pd]>[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[NH2:15])[CH:2]([CH3:4])[CH3:3]

Komponenten

4

Edukt 1

HCID 225904984-Isobutyl-3-nitro quinoline

Produkt 1

HCID 225904974-Isobutyl 3-amino quinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

The nitroxide group on the 4-isobutyl-3-nitro quinoline produced in Example 1 is reduced by catalytic reduction using toluene as solvent, Pd/C 5% (50% wet) as catalyst, at 40-45° C. and atmospheric pressure to produce 4-isobutyl 3-amino quinoline. The rate of reaction depends on efficiency of stirring. After catalyst filtration the solution is ready for the next step.

Quellen und Nachweise

ORD-Eintrag
ord-7ccd7f7189f341b1b43a770b427734af
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852861B2

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