HCID 69205838, Verbindung → HCID 69204178, Verbindung

HRID 2378275Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2378275
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)[OH:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)=[O:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

Komponenten

4

Edukt 1

HCID 69205838HCID 69205838, Verbindung

Produkt 1

HCID 69204178HCID 69204178, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysator2×HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl) -methanol from above and activated MnO2 (2.6 g, 30 mmol) in methylene chloride (30 if L) was stirred at room temperature for 18 h. More MnO2 (2 g) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone as a brown oil (1.58 g, 85% crude yield 2 steps). The sample was used in the next step without further purification.

Aufarbeitung

  1. waitkept for overnight
  2. filtrationThe suspension was filtered
  3. customRemoval of solvent

Quellen und Nachweise

ORD-Eintrag
ord-67d17ecd437d444ea959d2de81fb4211
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07470723B2

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