Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate → HCID 22558762, Verbindung

HRID 2378530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2378530
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>C(OCC)(=O)C.CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Komponenten

5

Edukt 1

HCID 53705486Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate

Produkt 1

HCID 22558762HCID 22558762, VerbindungAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of Intermediate 7 (3.01 g) in ethyl acetate (50 ml) and methanol (25 ml) was added with 10% palladium/carbon (300 mg, Merck), and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 8, 3.02 g).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3cec7341f3274df9a0847e009ebb01c9
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07470807B2

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