Hydrochloric Acid → HCID 5744998, Verbindung

Norpethidine (15.63 g, 67 mmol), 4-ethoxybutylchloride (10.67 g, 70 mmol), Na2CO3 (7.77 g, 73 mmol), KI (0.6 g) and acetonitrile (150 ml) were heated under reflux and stirring for 72 h. The mixture was filtered and the solvent removed. The residue was dissolved in diethyl ether, and the solution washed with water and dried (MgSO4). Destillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg. B.p. acc. to J. Chem. Soc. 3062 (1958) 180° C./1 mm Hg. Hydrochloride m.p. 143°-145° C.

1. temperatureunder reflux
2. filtrationThe mixture was filtered
3. customthe solvent removed
4. dissolutionThe residue was dissolved in diethyl ether
5. washthe solution washed with water
6. dry with materialdried (MgSO4)
7. customDestillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg
8. custom3062 (1958) 180° C./1 mm Hg

ORD-Eintrag

ord-352ed2c999c145d39e93b1de8b9e9709

Quelldatensatz

uspto-grants-1994_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05360805