Terazosin Hydrochloride → Terazosin

HRID 2379401

Reaktionsgleichung

Reaktionsgleichung von HRID 2379401
[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28].O.O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28]

Komponenten

3

Edukt 1

HCID 63016Terazosin Hydrochloride

Produkt 1

HCID 5401Terazosin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Terazosin monohydrochloride dihydrate (620 mg, 1.35 mmol) was dissolved in 100 mL of hot absolute ethanol in a 250 mL Erlenmeyer flask fitted with a ground glass joint. The solution was slowly cooled to room temperature and allowed to stand overnight. The resulting white crystalline precipitate was collected by vacuum filtration to yield 100 mg (0.24 mmol, 17.4%) of the anhydrous crystalline polymorph of terazosin of this invention. The material was found by its powder x-ray diffraction pattern to be free of both the prior art anhydrous crystalline modification and the dihydrate form.

Aufarbeitung

  1. customfitted with a ground glass joint
  2. filtrationThe resulting white crystalline precipitate was collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-d59d9fb764014b84b9b64fb74483d498
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05362730

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