1-Bromooctane → N-(6-Methylthioquinolin-5-yl)-2-octanyl-1,3-dithiane-2-carboxamide

HRID 2379614

Reaktionsgleichung

Reaktionsgleichung von HRID 2379614
[NH2:1][C:2]1[C:11]([S:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH2:14]([C:22]1([C:28](O)=[O:29])[S:27][CH2:26][CH2:25][CH2:24][S:23]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].S1CCCSC1C(O)=O.C[Si](C)(C)[N-][Si](C)(C)C.[Na+].C(Br)CCCCCCC>>[CH3:13][S:12][C:11]1[C:2]([NH:1][C:28]([C:22]2([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[S:23][CH2:24][CH2:25][CH2:26][S:27]2)=[O:29])=[C:3]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][CH:5]=[CH:4]2

Komponenten

6

Edukt 5

HCID 81401-BromooctaneHCID 3037051,3-Dithiane-2-carboxylic acidHCID 2724254Sodium bis(trimethylsilyl)amideHCID 103976605-Amino-6-methylthioquinolineHCID 149954362-Octanyl-1,3-dithiane-2-carboxylic acid

Produkt 1

HCID 14995437N-(6-Methylthioquinolin-5-yl)-2-octanyl-1,3-dithiane-2-carboxamide

Versuchsvorschrift

5-Amino-6-methylthioquinoline, prepared as described in Example 34, was coupled with 2-octanyl-1,3-dithiane-2-carboxylic acid, prepared by treatment of 1,3-dithiane-2-carboxylic acid with sodiumhexamethyldisilazide and octanyl bromide, according to Example 25 to give the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-08b1aa7724ff459d8e809d0af70249e0
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05362878

Verknüpfte Notizen

Wird geladen…