Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 2379692

Reaktionsgleichung

Reaktionsgleichung von HRID 2379692
[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Komponenten

5

Edukt 4

HCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 68114Atropic acid

Produkt 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamideAusbeute 28,9 %

Versuchsvorschrift

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate C9.2 ml, 70.9 mmol), and cyclohexylamine (8.1. ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131-133°. (Found: C, 78.7; H, 8.8; N, 5.95. C15H19NO requires C, 78.6; H, 8.35; N, 6.1%.)

Aufarbeitung

  1. customThe crude product was purified by recrystallisation from cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-cf2b8c01a3e149428f533c86fdc1e0b3
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364849

Verknüpfte Notizen

Wird geladen…