Acetaldehyde → 2-Acetylpyridine-4-carbonitrile
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.[CH:9](=[O:11])[CH3:10].S(=O)(=O)(O)O>O.C(OO)(C)(C)C>[C:9]([C:2]1[CH:3]=[C:4]([C:7]#[N:8])[CH:5]=[CH:6][N:1]=1)(=[O:11])[CH3:10]Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of ferrous sulfate heptahydrate (496 g) in water (1080 ml) and tert-butylhydroperoxide (173 ml) were simultaneously added to a solution of 4-pyridinecarbonitrile (30 g), acetaldehyde (97.6 ml) and sulfuric acid (15.4 ml) in water (90 ml) at 0° C. with stirring. After stirring at the same temperature for one hour, the resulting precipitate was collected by filtration and washed with water to give 2-acetyl-4-pyridinecarbonitrile (22.5 g).
Aufarbeitung
- stirringAfter stirring at the same temperature for one hour
- filtrationthe resulting precipitate was collected by filtration
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-43c5c63698f546928b26a6daf5667ebc
- Quelldatensatz
- uspto-grants-1994_11
- Patentnummer
- US05364871
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