Tetrahydrofuran → 2-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

HRID 2380055Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2380055
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH3:11].O1CCC[CH2:20]1>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[CH2:20][O:18]1

Komponenten

4

Edukt 2

HCID 8028Tetrahydrofuran2×HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

Produkt 1

HCID 189565362-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of dimethylsulphoxonium methylide (36.5 ml of a 0.6M solution in tetrahydrofuran) was added dropwise to a stirred solution of the product of part (ii) (4.36 g) in tetrahydrofuran (35 ml) at -20°. The solution was allowed to warm to room temperature and stirring was continued for 18 hours and then diluted with water. The mixture was extracted with ethyl acetate and the combined extracts were dried (Na2SO4). Evaporation of the solvent gave the title compound as an oil (4.50 g) which was used directly in the next stage.

Aufarbeitung

  1. extractionThe mixture was extracted with ethyl acetate
  2. dry with materialthe combined extracts were dried (Na2SO4)
  3. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-dda4588133a049e2b524c2b4358c2a79
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364938

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