2,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine → 6-(2-Fluorophenyl)pyridin-3-amine

HRID 2380399Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2380399
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:3]=1>CO.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[N:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 189555872,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine

Produkt 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 2,4-dichloro-3 -nitro-6-(2-fluorophenyl)pyridine (1.6 g, 5.6 mmol) in methanol (100 ml) was added a catalytic amount of 10% palladium on carbon (100 mg). The mixture was hydrogenated at 50 psi for 8 hours then filtered through celite. The methanol was removed under reduced pressure and the residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate. The extract was washed with brine, dried over sodium sulfate, filtered and concentrated to give 5-amino-2-(2-fluorophenyl)pyridine, which was used without further purification.

Aufarbeitung

  1. filtrationthen filtered through celite
  2. customThe methanol was removed under reduced pressure
  3. extractionthe residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate
  4. washThe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d6a4ffcff473467aa90dfde6a9ee9727
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05367077

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