Water → 1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine

HRID 238057

Reaktionsgleichung

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]=2[NH2:20])[NH:13][N:12]=1.[C:21]([O-])([O-])=O.[K+].[K+].[CH2:27](Br)[CH:28]([CH3:30])[CH3:29].O>CN(C=O)C>[CH2:21]([N:13]1[C:14]2=[N:15][CH:16]=[N:17][C:18]([NH2:20])=[C:19]2[C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[N:12]1)[CH2:27][CH:28]([CH3:30])[CH3:29]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (50 mg, 0.21 mmol) was dissolved in DMF (1.5 mL) and K2CO3 (110 mg, 0.8 mmol) and isobutyl bromide were added. The reaction was heated to 60° C. overnight, then cooled to RT and poured into water (30 mL). The precipitate was collected by filtration. ESI-MS (M+H)+ m/z calcd 332.2, found 332.3.

Aufarbeitung

temperaturecooled to RT
filtrationThe precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag: ord-d44d2eb8810545989474eba8845bad27
Quelldatensatz: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08642604B2

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