Ammonia → 4-Benzyloxy-5-methoxy-2-(4-methylbenzoyl)benzonitrile

HRID 2381242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2381242
[CH2:1]([O:8][C:9]1[C:10]([O:25][CH3:26])=[CH:11][C:12](Br)=[C:13]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)=[O:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cu][C:28]#[N:29].CN1CCCC1=O.N>O.C(OCC)(=O)C>[CH2:1]([O:8][C:9]1[C:10]([O:25][CH3:26])=[CH:11][C:12]([C:28]#[N:29])=[C:13]([C:15](=[O:16])[C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 222AmmoniaHCID 13387N-methyl-2-pyrrolidoneHCID 53629725(5-Benzyloxy-2-bromo-4-methoxyphenyl)p-tolylmethanoneHCID 178418546HCID 178418546, Verbindung

Produkt 1

HCID 583455504-Benzyloxy-5-methoxy-2-(4-methylbenzoyl)benzonitrileAusbeute 112 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

A mixture of (5-benzyloxy-2-bromo-4-methoxyphenyl)-p-tolylmethanone (reference example 10-1) (1.11 g), copper(I)cyanide (967 mg) and 1-methyl-2-pyrrolidinone (2 mL) was irradiated with microwave to heat at 200° C. for 10 min while stirring. Water, a 28% ammonia in water and ethyl acetate were added. The separated organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was triturated with diethyl ether to give the title compound (1.08 g).

Aufarbeitung

  1. customwas irradiated with microwave
  2. dry with materialThe separated organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-8cc61f0707c54dd58ee417a99f8df97d
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08258162B2

Notizen zur Reaktion

Wird geladen…