HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Aminoimidazole-4-carboxamide → Temozolomide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Aminoimidazole-4-carboxamide | HCID 9679 | — |
| Edukt | Methyl Isocyanate | HCID 12228 | — |
| Edukt | 5-diazo-1H-imidazole-4-carboxamide | HCID 136377446 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Temozolomide | HCID 5394 | — |
Reaktionsschritte
Med. Chem. 1984, 27, 196-201 describes a process wherein 5-amino-1H-imidazole-4-carboxamide is converted into 5-diazo-1H-imidazole-4-carboxamide, which is then cyclised with methylisocyanate in dichloromethane to provide a high yield of temozolomide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08258294B2 |
| Quelldatensatz | uspto-grants-2012_09 |
| ORD ID | ord-921888acf71f4518ac900a0a05f2b570 |
| Quellennotiz | uspto-grants-2012_09 |