Water → HCID 17962881, Verbindung

HRID 2382299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2382299
B(Br)(Br)Br.[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6].O>ClCCl>[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 962WaterHCID 25134Boron tribromideHCID 17962883HCID 17962883, Verbindung

Produkt 1

HCID 17962881HCID 17962881, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Boron tribromide (1.30 ml) was added dropwise to a cooled (0° C.) solution of 1-acetyl-6-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (0.9 g) in dichloromethane (75 ml). After stirring for 18 h, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water, 5% aq. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water, 5% aq. NaHCO3 and water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f58aefd7a4a946708817f87db6490463
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08258293B2

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