HCID 17772937, Verbindung → Methyl 4-(4-(hydroxymethyl)phenyl)butanoate

HRID 2382527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2382527
[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][CH:9]=1)=O>CO.[Pd]>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH2:5][CH2:6][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][OH:15])=[CH:12][CH:13]=1

Komponenten

4

Edukt 1

HCID 17772937HCID 17772937, Verbindung

Produkt 1

HCID 42609020Methyl 4-(4-(hydroxymethyl)phenyl)butanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-[4-(Hydroxymethyl)-phenyl]-4-oxo-butyric acid methyl ester (8 g, 36 mmol) is dissolved in methanol. Pd/C (0.8 g, 10% wt dry basis) is added. The flask is then sealed with a rubber septum and a balloon filled with H2 gas is applied to it. The heterogeneous mixture is then stirred for 4 hours after which the balloon and the stopper are removed and the hydrogen is allowed to escape. The reaction mixture is then filtered through a pad of diatomaceous earth (Celite®) and the filtrate so obtained is concentrated in vacuo to provide the desired product.

Aufarbeitung

  1. customThe flask is then sealed with a rubber septum
  2. additiona balloon filled with H2 gas
  3. customthe stopper are removed
  4. filtrationThe reaction mixture is then filtered through a pad of diatomaceous earth (Celite®)
  5. customthe filtrate so obtained
  6. concentrationis concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-79ebc2fac29f41bd8c4f4bf8d8b7beff
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263042B2

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