3-Amino-1,2-propanediol → HCID 25214205, Verbindung
Reaktionsgleichung
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[NH2:20][CH2:21][CH:22]([OH:25])[CH2:23][OH:24]>>[OH:25][CH:22]([CH2:23][OH:24])[CH2:21][NH:20][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared following procedure described for example 30 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 50 mg; 0.18 mmol; 1.0 eq.) and 3-amino-1,2-propanediol (1.0 mL) as a white powder (6 mg, 7%). HPLC, Rt: 1.65 min. (purity 99.5%). LC/MS, M+(ESI): 328.1, M−(ESI): 326.1.
Quellen und Nachweise
- ORD-Eintrag
- ord-15d4467794224227939ef3656af24cbe
- Quelldatensatz
- uspto-grants-2012_09
- Patentnummer
- US08263595B2