[C:1]([C:3]1[C:4]([CH3:28])=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([CH2:13]/[CH:14]=[CH:15]/[C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:8]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:7][CH2:6]2)#[N:2]>C(O)C.[Pd]>[C:1]([C:3]1[C:4]([CH3:28])=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:8]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:7][CH2:6]2)#[N:2]To a solution of 1,1-dimethylethyl 6-cyano-1-[(2E)-4-(ethyloxy)-4-oxo-2-buten-1-yl]-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate (Preparation 25; 530 mg, 1.38 mmol) in ethanol (20 ml) under nitrogen was added palladium on carbon (106 mg, 0.100 mmol). The resulting mixture was stirred under an atmosphere of hydrogen (1 bar) for 105 min. The catalyst was filtered off through Celite® and the filtrate concentrated in vacuo to give the title compound (530 mg).
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