5-Aminopentan-1-ol → N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide

HRID 2385

Reaktionsgleichung

Reaktionsgleichung von HRID 2385
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10]C)=O)[CH:4]=[O:5])=[CH2:2].[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C[O-].[Na+]>CO>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][NH:12][C:8](=[O:10])[CH2:7][CH2:6][N:3]([CH:1]=[CH2:2])[CH:4]=[O:5]

Komponenten

5

Edukt 3

HCID 756345-Aminopentan-1-olHCID 10942334Sodium MethoxideHCID 10964771methyl 3-(N-vinylformamido)propionate

Produkt 1

HCID 19690346N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

The apparatus of Example 2 was charged with 15.7 grams (0.1 mol) of methyl 3-(N-vinylformamido)propionate, 10.3 grams (0.1 mol) of 5-amino-1-pentanol and 0.12 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 3 hours after which the methanol coproduct was removed by distillation at reduced pressure. NMR analysis of the remaining amber liquid indicated about 69% conversion to the desired product.

Aufarbeitung

  1. customwas removed by distillation at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-575fdaab9b024e09a2ac34fb099e5fd0
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728878

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