Ethylene Glycol → 2-hydroxyethyl 3-(N-vinylformamido)propionate

HRID 2386

Reaktionsgleichung

Reaktionsgleichung von HRID 2386
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:4]=[O:5])=[CH2:2].C(O)C[OH:15].C[O-].[Na+].C(O)C>CO>[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10][CH2:11][CH2:12][OH:15])=[O:9])[CH:4]=[O:5])=[CH2:2]

Komponenten

6

Edukt 4

HCID 174Ethylene GlycolHCID 702EthanolHCID 10942334Sodium MethoxideHCID 19690337ethyl 3-(N-vinylformamido)propionate

Produkt 1

HCID 196903422-hydroxyethyl 3-(N-vinylformamido)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

The apparatus of Example 2 was charged with 17.1 grams (0.1 mol) of ethyl 3-(N-vinylformamido)propionate, 6.2 grams (0.1 mol) of ethylene glycol, and 0.15 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 2 hours. No evolution of ethanol was observed during the reaction period. Heating for an additional hour at 135° C. also failed to generate a volatile coproduct which indicated no conversion to the desired product.

Aufarbeitung

  1. temperatureHeating for an additional hour at 135° C.

Quellen und Nachweise

ORD-Eintrag
ord-9263fd3c38db4e7d8af1acf74087dcb3
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728878

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