1-Fluoro-4-(methylsulphonyl)benzene → [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

HRID 238612

Reaktionsgleichung

Reaktionsgleichung von HRID 238612
[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:14]([CH3:15])=[C:13]([OH:16])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:17])[CH:11]=2)[CH:6]=1.F[C:20]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=1.COC(=O)C(=CC1C=CC(F)=CC=1)CC(O)=O>>[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:14]([CH3:15])=[C:13]([O:16][C:20]2[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:17])[CH:11]=2)[CH:6]=1

Komponenten

4

Edukt 3

HCID 679941-Fluoro-4-(methylsulphonyl)benzeneHCID 59326538(6-Chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl esterHCID 673037992-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester

Produkt 1

HCID 59326613[6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl esterAusbeute 33,4 %

Versuchsvorschrift

Starting with (6-chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (132 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 33%) was obtained as a yellow oil.

Quellen und Nachweise

ORD-Eintrag
ord-a59767866add42b69dd7390a8d6045d1
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642629B2

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