4-Benzyloxy-6-fluoro-3-methyl-naphthalene-2-carbaldehyde → HCID 59326572, Verbindung

HRID 238626

Reaktionsgleichung

Reaktionsgleichung von HRID 238626
C([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:19])[CH:17]=2)[CH:12]=[C:11]([CH:20]=[O:21])[C:10]=1[CH3:22])C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[F:19][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH:20]=[O:21])[C:10]([CH3:22])=[C:9]2[OH:8]

Komponenten

4

Edukt 1

HCID 593265294-Benzyloxy-6-fluoro-3-methyl-naphthalene-2-carbaldehyde

Produkt 1

HCID 59326572HCID 59326572, VerbindungAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-benzyloxy-6-fluoro-3-methyl-naphthalene-2-carbaldehyde (165 mg, 0.56 mmol) in ethyl acetate (5 mL) was added 10% palladium on carbon (7 mg). The resulting mixture was stirred vigorously under a hydrogen atmosphere (balloon) for 4 hours, and then filtered. The filtrate was concentrated in vacuo to give 6-fluoro-4-hydroxy-3-methyl-naphthalene-2-carbaldehyde (115 mg, 99%) as a yellow solid which was directly used in the next step without further purification.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6262dd8b0ff64a71bd52d0cab5c04325
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642629B2

Verknüpfte Notizen

Wird geladen…