Methanesulfonyl chloride → 4-{[5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzyl]-methanesulfonyl-amino}-piperidine-1-carboxylic acid tert-butyl ester

HRID 2386472

Reaktionsgleichung

Reaktionsgleichung von HRID 2386472
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([Cl:28])[N:23]=3)[CH:19]=[CH:18][C:17]=2[F:29])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:30][S:31](Cl)(=[O:33])=[O:32]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:15][C:16]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([Cl:28])[N:23]=3)[CH:19]=[CH:18][C:17]=2[F:29])[S:31]([CH3:30])(=[O:33])=[O:32])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 866032934-[5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzylamino]-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 866032944-{[5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzyl]-methanesulfonyl-amino}-piperidine-1-carboxylic acid tert-butyl ester

Versuchsvorschrift

Intermediate 90 was coupled with methanesulfonyl chloride following procedure D LC-MS showed the product was >95% pure and had the expected M+H+ of 499.

Quellen und Nachweise

ORD-Eintrag
ord-8ccbf286e30e44f79752adc6fb653b6c
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268822B2

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