(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptan-1-ol → (S)-3-aminoheptan-1-ol

HRID 2387791Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2387791
C([N:8]([C@H](C1C=CC=CC=1)C)[C@@H:9]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:10][CH2:11][OH:12])C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C@@H:9]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:10][CH2:11][OH:12]

Komponenten

4

Edukt 1

HCID 68752972(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptan-1-ol

Produkt 1

HCID 55290391(S)-3-aminoheptan-1-olAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysator2×HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of the product from step (iv) (5 g) and 5% Pd/C (0.5 g) in EtOH (25 mL) was hydrogenated under 5 bar at rt for 5 days. A further portion of 5% Pd/C (1.5 g) was added, and the reaction mixture hydrogenated under 5 bar at rt for a further 1 day. The reaction mixture was filtered and the solvent evaporated to give the subtitle compound 1.8 g.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bfa52c3e9e8c42bd8f27ad6e6f30621d
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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