Dimethylformamide → HCID 178500165, Verbindung

HRID 2389183Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389183
C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[N+:12]([CH:15]([C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:27][C@H:28]3[CH2:33][CH2:32][C@H:31]([C:34]([F:37])([F:36])[F:35])[CH2:30][CH2:29]3)[CH:23]=2)[CH:18]=1)[CH3:16])([O-:14])=[O:13].[C:38]([O:42][CH3:43])(=[O:41])[CH:39]=[CH2:40]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)(=O)C>[CH3:43][O:42][C:38](=[O:41])[CH2:39][CH2:40][C:15]([N+:12]([O-:14])=[O:13])([C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:27][C@H:28]3[CH2:29][CH2:30][C@H:31]([C:34]([F:37])([F:36])[F:35])[CH2:32][CH2:33]3)[CH:23]=2)[CH:18]=1)[CH3:16]

Komponenten

7

Edukt 4

HCID 6228DimethylformamideHCID 7294Methyl AcrylateHCID 11430Potassium CarbonateHCID 178435549HCID 178435549, Verbindung

Produkt 1

HCID 178500165HCID 178500165, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a mixture of potassium carbonate (78 mg, 0.56 mmol, Fisher), tetrabutylammonium hydrogen sulfate (10. mg, 0.029 mmol, Aldrich) and N,N-dimethylformamide (2.00 mL, Acros) was added 2-(1-nitro-ethyl)-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalene (0.159 g, 0.433 mmol). The mixture was stirred and methyl acrylate (50 μL, 0.56 mmol, Aldrich) was added. The mixture was stirred at room temperature. After 2 h, ethyl acetate was added and the solution was washed with saturated ammonium chloride, then saturated sodium chloride. The organics were dried over Na2SO4, filtered, concentrated. The residue was taken up in DCM, and silica gel was added. The solvent was removed and the residue was purified by silica gel chromatography (0-25% EtOAc in hexanes). Isolated was 98 mg (50%) of product (Rf=0.19 in 7:1 hexanes/ethyl acetate).

Aufarbeitung

  1. stirringThe mixture was stirred at room temperature
  2. washthe solution was washed with saturated ammonium chloride
  3. dry with materialThe organics were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. additionsilica gel was added
  7. customThe solvent was removed
  8. customthe residue was purified by silica gel chromatography (0-25% EtOAc in hexanes)
  9. customIsolated

Quellen und Nachweise

ORD-Eintrag
ord-e5f79036b14947b19a3f6af78028afc4
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08269043B2

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