{3-[3-(Benzyloxy)phenyl]propoxy}(tert-butyl)dimethylsilane → HCID 68536344, Verbindung

HRID 2389347Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389347
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][O:18][Si:19]([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[Si:19]([O:18][CH2:17][CH2:16][CH2:15][C:11]1[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=1)([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]

Komponenten

4

Edukt 1

HCID 68535354{3-[3-(Benzyloxy)phenyl]propoxy}(tert-butyl)dimethylsilane

Produkt 1

HCID 68536344HCID 68536344, VerbindungAusbeute 82,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of {3-[3-(benzyloxy)phenyl]propoxy}(tert-butyl)dimethylsilane (2.90 g) in MeOH (30 mL) was added 10% palladium on carbon (300 mg) and the mixture was stirred at ambient temperature for 3 hours under hydrogen atmosphere (3 atm). The mixture was filtered through a bed of Celite. The filtrate was evaporated in vacuo to afford 3-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)phenol (1.78 g) as a colorless oil.

Aufarbeitung

  1. filtrationThe mixture was filtered through a bed of Celite
  2. customThe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0cafebcab2f74560b6602f2e99d3cc93
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273745B2

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