Potassium Carbonate → HCID 68536367, Verbindung

Reaktionsgleichung

C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([NH:13][CH2:14][CH2:15][N:16]2[CH:21]=[C:20]([CH:22]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:19]=[CH:18][C:17]2=[O:35])=[O:12])[CH:6]=1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO.O>[C:23]1([CH:22]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:20]2[CH:19]=[CH:18][C:17](=[O:35])[N:16]([CH2:15][CH2:14][NH:13][C:11](=[O:12])[C:7]3[CH:8]=[CH:9][CH:10]=[C:5]([OH:4])[CH:6]=3)[CH:21]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Komponenten

Versuchsvorschrift

To a solution of 3-[({2-[5-(diphenylmethyl)-2-oxo-1(2H)-pyridinyl]ethyl}amino)carbonyl]phenyl acetate (77.0 mg) in MeOH (2.3 mL) was added portionwise K2CO3 (68.4 mg) at ambient temperature and the mixture was stirred at the same temperature for 15 minutes. The resulting mixture was diluted with water (5.0 mL) and the aqueous solution was extracted with EtOAc (10.0 mL). The organic layer was washed successively with 1M HCl aqueous solution, saturated NaHCO3 aqueous solution and brine, dried over anhydrous MgSO4, filtered and evaporated in vacuo to give N-{2-[5-(diphenylmethyl)-2-oxo-1(2H)-pyridinyl]ethyl}-3-hydroxybenzamide (70 mg) as a off-white amorphous powder.