Hydrochloric Acid → HCID 178517482, Verbindung

HRID 2389736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389736
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](SCC)[N:12]2[CH:18]=[CH:19][N:20]=[C:11]2[CH:10]=1.[OH-:21].[K+].Cl.[Cl-].[NH4+]>CO.O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([OH:21])[N:12]2[CH:18]=[CH:19][N:20]=[C:11]2[CH:10]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 25517Ammonium ChlorideHCID 593131257-(2,4-Dichlorophenyl)-5-(ethylthio)imidazo[1,2-c]pyrimidine

Produkt 1

HCID 178517482HCID 178517482, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

16.6 g (51.19 mmol) of 7-(2,4-dichlorophenyl)-5-(ethylthio)imidazo[1,2-c]pyrimidine are dissolved in 330 ml of methanol, and 77 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is stirred at the reflux temperature for 2 h. After cooling, 300 ml of water are added and then, while cooling in ice, 140 ml of 0.1 molar hydrochloric acid. The mixture is then neutralized with saturated aqueous ammonium chloride solution and stirred for 10 min, and the solid is filtered off with suction. It is thoroughly washed with water and dried under high vacuum. 13.6 g (92% of theory) of the product are obtained as a solid.

Aufarbeitung

  1. temperatureAfter cooling
  2. temperaturewhile cooling in ice
  3. stirringstirred for 10 min
  4. filtrationthe solid is filtered off with suction
  5. washIt is thoroughly washed with water
  6. customdried under high vacuum
  7. custom13.6 g (92% of theory) of the product are obtained as a solid

Quellen und Nachweise

ORD-Eintrag
ord-2ae1383944af46378ac96d0d9e6f5ae9
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273752B2

Notizen zur Reaktion

Wird geladen…