Tetrahydrofuran → 2-Bromo-4-(isopropylsulfonyl)-1-methylbenzene

HRID 2390161Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2390161
[Br:1][C:2]1[CH:7]=[C:6](SC(C)C)[CH:5]=[CH:4][C:3]=1[CH3:12].O[O:14][S:15]([O-:17])=O.[K+].[CH2:19]1[CH2:23]OC[CH2:20]1>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([S:15]([CH:19]([CH3:23])[CH3:20])(=[O:17])=[O:14])[CH:5]=[CH:4][C:3]=1[CH3:12]

Komponenten

6

Edukt 3

HCID 8028TetrahydrofuranHCID 23707502Potassium hydroxy sulfiteHCID 585218832-Bromo-4-(isopropylthio)-1-methylbenzene

Produkt 1

HCID 585220592-Bromo-4-(isopropylsulfonyl)-1-methylbenzeneAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A cooled (0° C.) solution of 2-bromo-4-(isopropylthio)-1-methylbenzene (123 mg) in THF (10 ml) was treated with a solution of oxone (580 mg) in water (6 ml). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and concentrated to give the title compound (120 mg, 92%).

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-2cddf8cfcee24c709daf6588306fcb07
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273769B2

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