Water → HCID 86611704, Verbindung
Reaktionsgleichung
[OH2:1].Br[CH2:3][C:4]1[C:12]2[C:7](=[N:8][C:9]([Cl:13])=[CH:10][CH:11]=2)[S:6][N:5]=1>CS(C)=O>[Cl:13][C:9]1[N:8]=[C:7]2[S:6][N:5]=[C:4]([CH2:3][OH:1])[C:12]2=[CH:11][CH:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
Water (8 mL) was added to a solution of 3-(bromomethyl)-6-chloroisothiazolo[5,4-b]pyridine (19.0 mmol) in dimethylsulfoxide (40 mL) and the reaction mixture was heated at 80° C. for 1.5 h. The reaction mixture was then quenched with water (50 mL) and the resulting solution was extracted with ethyl acetate (3×40 mL). The combined organic layers were dried (magnesium sulfate) and concentrated to provide the crude (6-chloroisothiazolo[5,4-b]pyridin-3-yl) methanol as a yellow solid.