Methanol → Methyl 3-(1,2-benzisoxazol-3-yl)propionate

Reaktionsgleichung

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]#N)=[N:2]1.CC[O:16][CH2:17]C.C[OH:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]([O:16][CH3:17])=[O:20])=[N:2]1

Komponenten

Edukt 3

HCID 887Methanol

HCID 3283Diethyl Ether

HCID 1227915159899-56-8

Produkt 1

HCID 22012185Methyl 3-(1,2-benzisoxazol-3-yl)propionate

Versuchsvorschrift

The nitrile was dissolved in methanol (200 ml) and HCI-saturated ether (200 ml) was added followed by stirring for 16 h at room temperature. The reaction mixture was concentrated in vacuo, water and ether added, and the phases separated. Drying of the ether phase over magnesium sulfate and removal of solvent in vacuo gave methyl 3-(1,2-benzisoxazol-3-yl)propionate (13 g) as an oil.

Aufarbeitung

concentrationThe reaction mixture was concentrated in vacuo, water and ether
additionadded
customthe phases separated
dry with materialDrying of the ether phase over magnesium sulfate and removal of solvent in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-1fe95c5ef52b4167b23aeae7c40ee946
Quelldatensatz: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05807871

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