Dimethyl Sulfoxide → HCID 18977180, Verbindung

HRID 2393736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393736
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][CH:7]=1.[BrH:19].C(O)(=O)C.CS(C)=O.C(OC(C)C)(C)C>C(O)(=O)C>[BrH:19].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:10][CH:11]=1

Komponenten

6

Edukt 4

HCID 679Dimethyl SulfoxideHCID 7914Diisopropyl EtherHCID 18977184HCID 18977184, VerbindungHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Produkt 1

HCID 18977180HCID 18977180, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

In 200 ml of acetic acid was suspended 15.00 g of 6-[4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one. To the suspension were added 100 ml of a 25% hydrogen bromide-acetic acid solution and then 5.35 g of dimethylsulfoxide, and the mixture was stirred at room temperature for 4.5 hours. 400 ml of isopropyl ether was added to the reaction mixture, and precipitated crystal was collected by filtration and recrystallized from methanol to obtain 18.94 g of 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide.

Aufarbeitung

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-2261f0e9b39b48fbb6b01f54c9e9a307
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05808065

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