Water → 7-Methoxyresorufin

HRID 2395168

Reaktionsgleichung

Reaktionsgleichung von HRID 2395168
S(OC)(O[CH3:5])(=O)=O.[CH:8]1[C:13]([OH:14])=[CH:12][C:11]2[O:15][C:16]3[C:22](=[N:23][C:10]=2[CH:9]=1)[CH:21]=[CH:20][C:18](=[O:19])[CH:17]=3.C(=O)([O-])[O-].[K+].[K+].O>COCCOCCN(CCOCCOC)CCOCCOC.O1CCOCC1>[CH3:5][O:14][C:13]1[CH:8]=[CH:9][C:10]2[N:23]=[C:22]3[C:16]([O:15][C:11]=2[CH:12]=1)=[CH:17][C:18](=[O:19])[CH:20]=[CH:21]3

Komponenten

7

Edukt 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 69462Resorufin

Produkt 1

HCID 1192207-MethoxyresorufinAusbeute 59,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-KatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

12.1 ml of dimethyl sulphate were added at room temperature while stirring well to a suspension of 20.0 g (85.0 mmol) of resorufin, 17.6 g of freshly powdered potassium carbonate and 10 drops of tris-[2-(2-methoxyethoxy)ethyl]amine in 150 ml of dioxan. The reaction mixture was subsequently stirred at 100° for 2 hours, cooled and then treated with 150 ml of water. The solid was filtered off, washed with water and dried over phosphorus pentoxide. 11.5 g (59.5%) of resorufin methyl ether of m.p. 240°-244° (dec.) were obtained.

Aufarbeitung

  1. temperaturecooled
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. dry with materialdried over phosphorus pentoxide

Quellen und Nachweise

ORD-Eintrag
ord-e2b94f41fb7d44e8a07dc4a93139aed0
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05811548

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