Acetic Acid → 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine

HRID 23960

Reaktionsgleichung

Reaktionsgleichung von HRID 23960
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH:14]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[CH2:15].C(O)(=O)C>C(O)C>[C:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:15][CH2:14][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 75024-VinylpyridineHCID 143452tert-Butyl piperazine-1-carboxylate

Produkt 1

HCID 223216311-Boc-4-[2-(4-pyridinyl)ethyl]piperazineAusbeute 46,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide 1-Boc-4-[2-(4-pyridinyl)ethyl]-piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 48 h
  3. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0cbde3c2a82a4113837f2babf03f86ec
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855715B1

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