Water → 5-chloro-N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methyl-pentanesulfonamide

HRID 2396697Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2396697
Cl.[F:2][C:3]([F:14])([C:7]([F:13])([F:12])[C:8]([F:11])([F:10])[F:9])[CH2:4][NH:5][CH3:6].C(N(CC)CC)C.[Cl:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][S:28](Cl)(=[O:30])=[O:29].O>C(Cl)Cl>[Cl:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][S:28]([N:5]([CH2:4][C:3]([F:14])([F:2])[C:7]([F:12])([F:13])[C:8]([F:9])([F:10])[F:11])[CH3:6])(=[O:30])=[O:29]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 12589202HCID 12589202, VerbindungHCID 19711030N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methylamine hydrochloride

Produkt 1

HCID 197110325-chloro-N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methyl-pentanesulfonamideAusbeute 101,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

500 mg of N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methylamine hydrochloride (obtained according to European Patent No. 384,842 Example 75) and then, at 0° to 5° C., 0.55 ml of triethylamine were added to a solution of 200 mg of 5-chloropentane sulfonyl chloride in 5 ml of methylene chloride, and the mixture was stirred at ambient temperature for 2 hours. Water was added and extraction was carried out with methylene chloride. The extracts were washed with water, then with a saturated aqueous solution of sodium chloride, dried and evaporated to dryness under reduced pressure to obtain 378 mg of the expected product.

Aufarbeitung

  1. extractionextraction
  2. washThe extracts were washed with water
  3. dry with materialwith a saturated aqueous solution of sodium chloride, dried
  4. customevaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cd1124b253f14996ab83dd124799145d
Quelldatensatz
uspto-grants-1996_02
Patentnummer
US05494907

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