p-Toluenesulfonic acid → Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate

HRID 2396950

Reaktionsgleichung

Reaktionsgleichung von HRID 2396950
[CH3:1][C:2]1[C:7]([C:8]([CH:10](C(OCC)=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:7]([C:8]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24]

Komponenten

4

Edukt 2

HCID 6101p-Toluenesulfonic acidHCID 53783746Diethyl 6-methyl-2,3,4,5-tetrafluorobenzoylmalonate

Produkt 1

HCID 14774100Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetateAusbeute 70,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To diethyl 6-methyl-2,3,4,5-tetrafluorobenzoylmalonate (8 g) are added water (20 ml) and p-toluenesulfonic acid (80 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate (4.5 g).

Aufarbeitung

  1. temperaturethe mixture is refluxed for 2.5 hours
  2. temperatureAfter cooling
  3. extractionthe resultant is extracted with diethyl ether
  4. dry with materialthe extract is dried over magnesium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7c0507db4c234d23b0f4872a194c5e50
Quelldatensatz
uspto-grants-1996_02
Patentnummer
US05495020

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