Propionic anhydride → 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline

HRID 2397546

Reaktionsgleichung

Reaktionsgleichung von HRID 2397546
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH2:12])[C:6]([NH2:13])=[N:5]2.[C:14](OC(=O)CC)(=O)[CH2:15][CH3:16]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]1[NH:12][C:14]([CH2:15][CH3:16])=[N:13][C:6]1=[N:5]2

Komponenten

4

Edukt 2

HCID 31263Propionic anhydrideHCID 125173906-Chloroquinoxaline-2,3-diamine

Produkt 1

HCID 1784375416-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Four parts of 6-chloro-2,3-diaminoquinoxaline was combined with 3 parts of propionic anhydride in 2 parts of tetrahydrofuran. The mixture was heated for three hours during which time a thick slurry formed. The solid was collected from the hot mixture by filtration and washed twice with two parts of tetrahydrofuran. The gray solid was air-dried to give four parts of 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline, m.p. 298°-300°.

Aufarbeitung

  1. temperatureThe mixture was heated for three hours during which time a thick slurry
  2. customformed
  3. filtrationThe solid was collected from the hot mixture by filtration
  4. washwashed twice with two parts of tetrahydrofuran
  5. customThe gray solid was air-dried

Quellen und Nachweise

ORD-Eintrag
ord-9e35a6b9f5a54dd29f6ad807ad3dde7b
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04022777

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