Tetrafluoroboric acid → 4-Fluoro-3,5-dimethoxybenzaldehyde

HRID 2398068Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2398068
N[C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[H+].[B-](F)(F)(F)[F:16].N([O-])=O.[Na+]>O>[CH3:13][O:12][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:10][CH3:11])[C:2]=1[F:16])[CH:6]=[O:7]

Komponenten

5

Edukt 3

HCID 28118Tetrafluoroboric acidHCID 200429634-Amino-3,5-dimethoxybenzaldehydeHCID 23668193Sodium Nitrite

Produkt 1

HCID 123984494-Fluoro-3,5-dimethoxybenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.4 g. of 4-amino-3,5-dimethoxybenzaldehyde in 20 ml. of 50% hydrogen tetrafluoroborate was diazotized at 0° C. with a solution of 0.59 g. of sodium nitrite in about 2 ml. of water. After irradiation with a low pressure mercury lamp (Hanau NK 6620) for 6 hours at room temperature, the solution was extracted with ether, the ether extracts dried over magnesium sulfate and concentrated. After recrystallization from heptane, the residue produced 3,5-dimethoxy-4-fluoro-benzaldehyde of melting point 97°-98° C.

Aufarbeitung

  1. customwas diazotized at 0° C. with a solution of 0.59 g
  2. customAfter irradiation with a low pressure mercury lamp (Hanau NK 6620) for 6 hours at room temperature
  3. extractionthe solution was extracted with ether
  4. dry with materialthe ether extracts dried over magnesium sulfate
  5. concentrationconcentrated
  6. customAfter recrystallization from heptane

Quellen und Nachweise

ORD-Eintrag
ord-3006afe8a3834b078468d63dfc04a110
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04024145

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