Water → Propanenitrile, 2-methyl-2-(methylsulfonyl)-

HRID 239906

Reaktionsgleichung

Reaktionsgleichung von HRID 239906
[CH3:1][S:2]([CH2:5][C:6]#N)(=[O:4])=[O:3].[CH3:8]I.[H-].[Na+].O.C[N:14]([CH3:17])C=O>>[CH3:8][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])([CH3:6])[C:17]#[N:14]

Komponenten

6

Edukt 5

HCID 962WaterHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 75283(Methylsulfonyl)acetonitrile

Produkt 1

HCID 3014848Propanenitrile, 2-methyl-2-(methylsulfonyl)-Ausbeute 58 %

Versuchsvorschrift

To a solution of methylsulfonylacetonitrile (25 g) and methyl iodide (27.4 mL) in N,N-dimethylformamide (300 mL) was added sodium hydride (20 g) at 0° C., and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (18 g, yield 58%) as colorless crystals.

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e00a7859e5e942a5988e009082c9e4a9
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642770B2

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