Potassium Carbonate → N-[2-(2-Pyridylmethylthio)ethyl]thiourea

HRID 2399125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2399125
C([NH:9][C:10]([NH:12][CH2:13][CH2:14][S:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][S:15][CH2:14][CH2:13][NH:12][C:10]([NH2:9])=[S:11]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 21432770N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea

Produkt 1

HCID 21432760N-[2-(2-Pyridylmethylthio)ethyl]thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The benzoyl thiourea is added to a solution of potassium carbonate (1.4 g.) in water (80 ml.) at 60°. The solution is maintained at this temperature for one hour, concentrated to low bulk and acidified with hydrochloric acid. Benzoic acid is removed by filtration and the filtrate is basified with potassium carbonate and concentrated under reduced pressure. Following extraction with isopropyl alcohol and concentration, the product is N-[2-(2-pyridylmethylthio)ethyl]thiourea.

Aufarbeitung

  1. temperatureThe solution is maintained at this temperature for one hour
  2. concentrationconcentrated to low bulk
  3. customBenzoic acid is removed by filtration
  4. concentrationconcentrated under reduced pressure
  5. extractionextraction
  6. concentrationwith isopropyl alcohol and concentration

Quellen und Nachweise

ORD-Eintrag
ord-fa2c0217bf0a41358db4f7b440311365
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04027026

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