o-CRESYL GLYCIDYL ETHER → 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol

HRID 2399161

Reaktionsgleichung

Reaktionsgleichung von HRID 2399161
[CH2:1]([NH:8][C:9]([CH3:22])([CH3:21])[CH2:10][O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH2:18])=[O:17])=[CH:14][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][C:24]1[CH:34]=[CH:33][CH:32]=[CH:31][C:25]=1[O:26][CH2:27][CH:28]1[O:30][CH2:29]1>C(O)(C)C>[CH2:1]([N:8]([CH2:29][CH:28]([OH:30])[CH2:27][O:26][C:25]1[CH:31]=[CH:32][CH:33]=[CH:34][C:24]=1[CH3:23])[C:9]([CH3:22])([CH3:21])[CH2:10][O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](=[O:17])[NH2:18])=[CH:14][N:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 16640o-CRESYL GLYCIDYL ETHERHCID 539610346-(2-Benzylamino-2,2-dimethylethoxy)-nicotinic acid amide

Produkt 1

HCID 213332331-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 12 g of 6-(2-benzylamino-2,2-dimethylethoxy)-nicotinic acid amide and 12 g of 1-(2-methylphenoxy)2,3-epoxy-propane in 150 ml of isopropanol is boiled for 28 hours under reflux. After working up analogously to Example 1(c), crude 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol is obtained, which is used further without additional purification.

Aufarbeitung

  1. temperatureunder reflux

Quellen und Nachweise

ORD-Eintrag
ord-11cc49ab95dc4db1930c434929592b4a
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04027027

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