Benzene, (2-chloroethoxy)- → Phenoxyethyl-norfentanyl

HRID 2399172

Reaktionsgleichung

Reaktionsgleichung von HRID 2399172
[C:1]1([N:7]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:8](=[O:11])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:18]([CH2:25][CH2:26]Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[O:18]([CH2:25][CH2:26][N:15]1[CH2:14][CH2:13][CH:12]([N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:11])[CH2:9][CH3:10])[CH2:17][CH2:16]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

3

Edukt 2

HCID 12156Benzene, (2-chloroethoxy)-HCID 2593814-(N-Propionylaniline)piperidine

Produkt 1

HCID 54005394Phenoxyethyl-norfentanylAusbeute 98,6 %

Versuchsvorschrift

By condensing 14.7 g 4-(N'-phenyl-N'-propionylamino)-piperidine and 19.9 g phenoxyethyl chloride, they are obtained after 24 hours reflux 22 g of the title product which after recrystallization from hot cyclohexane gives a first crop weighing 13.5 g. The pure compound melts at 100°-102°. It is soluble in hydrochloric acid. The solution after distillation leads to the recovery of the hydrochloride. The hydrochloride is soluble in water.

Aufarbeitung

  1. customare obtained after 24 hours

Quellen und Nachweise

ORD-Eintrag
ord-06dc97e744cf48a0a7842a8396006747
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04027028

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