Carbon Tetrachloride → 4-(Bromomethyl)-3-chlorobenzene-1-sulfonyl chloride

HRID 2399924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2399924
[Br:1]N1C(=O)CCC1=O.Cl[C:10]1[CH:11]=[C:12](C)[CH:13]=[CH:14][C:15]=1[S:16]([Cl:19])(=[O:18])=[O:17].C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[C:39]([Cl:43])(Cl)(Cl)Cl>>[Cl:43][C:39]1[CH:10]=[C:15]([S:16]([Cl:19])(=[O:18])=[O:17])[CH:14]=[CH:13][C:12]=1[CH2:11][Br:1]

Komponenten

5

Edukt 4

HCID 5943Carbon TetrachlorideHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 2890812-Chloro-4-methylbenzene-1-sulfonyl chloride

Produkt 1

HCID 193849654-(Bromomethyl)-3-chlorobenzene-1-sulfonyl chlorideAusbeute 14 %

Versuchsvorschrift

N-Bromosuccinimide (13.76 g, 76 mmol) was added to a stirred solution of 3-chloro-4-toluenesulphonyl chloride (12 g, 76 mmol) in CCl4 (120 ml) under argon. After one hour benzoyl peroxide (0.92 g, 3.8i mmol) was added and the reaction mixture refluxed overnight. The mixture was allowed to cool, the resulting white precipitate filtered off and the filtrate evaporated to a yellow oil. PurifiCation of the residue by chromatography over silica gel (3% ethyi acetate in hexane) afforded 3-chloro-4-bromomethylphenylsulphonyl chloride (3.3 g, 14%) as a colourless oil.

Aufarbeitung

  1. temperaturethe reaction mixture refluxed overnight
  2. temperatureto cool
  3. filtrationthe resulting white precipitate filtered off
  4. customthe filtrate evaporated to a yellow oil
  5. customPurifiCation of the residue by chromatography over silica gel (3% ethyi acetate in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-09312d978a814ace873a93a413821fc3
Quelldatensatz
uspto-grants-1995_09
Patentnummer
US05451676

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