1,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate → 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine

HRID 2400082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2400082
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[C:19]([O:18][C:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]

Komponenten

4

Edukt 1

HCID 544893721,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate

Produkt 1

HCID 537161023-(Boc-aMinoMethyl)-3-hydroxypyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 23938PalladiumLösungsmittel

Versuchsvorschrift

18.7 g (61 mmol) of 1-benzyl-3-tert.-butoxycarbonylaminomethyl-3-hydroxypyrrolidine are dissolved in 120 ml of methanol and hydrogenated on 3 g of 5% strength Pd/active carbon at 90° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is recrystallized from ethyl acetate.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe residue is recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-792d1892bf3d4eee9a0d09dcacf84906
Quelldatensatz
uspto-grants-1995_09
Patentnummer
US05453422

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