Water → HCID 178492676, Verbindung

HRID 2400140

Reaktionsgleichung

Reaktionsgleichung von HRID 2400140
[CH:1]1[C:7]([F:8])=[C:6]([NH2:9])[NH:5][C:3](=[O:4])[N:2]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16].O>N1C=CC=CC=1>[F:8][C:7]1[C:6]([NH:9][C:15](=[O:16])[C:14]2[CH:13]=[C:12]([O:11][CH3:10])[C:20]([O:21][CH3:22])=[C:19]([O:23][CH3:24])[CH:18]=2)=[N:5][C:3](=[O:4])[NH:2][CH:1]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 3366FlucytosineHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-

Produkt 1

HCID 178492676HCID 178492676, VerbindungAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a suspension of 12.9 g of fluorocytosine in 78 ml of pyridine was added 23.1 g of 3,4,5-trimethoxybenzoyl chloride, and the mixture was reacted at 100° C. for 5 hours. After the completion of reaction, the reaction mixture was poured into 300 ml of water at room temperature with stirring. After stirring the resulting mixture for additional 3 hours, the precipitated crystals were collected by filtration, washed with water and then dried to obtain 29.2 g of 5-fluoro-N4 -(3,4,5-trimethoxybenzoyl)cytosine.

Aufarbeitung

  1. customthe mixture was reacted at 100° C. for 5 hours
  2. customAfter the completion of reaction
  3. stirringAfter stirring the resulting mixture for additional 3 hours
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-74bbda3b21bf49d39a67dd17c73c7013
Quelldatensatz
uspto-grants-1995_09
Patentnummer
US05453497

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