Pyridine → Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

HRID 2401258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2401258
N1C=CC=CC=1.[F:7][C:8]([F:17])([F:16])[C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][N:10]=1.Cl[C:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:20]>C(Cl)(Cl)Cl>[C:22]1([O:21][C:19](=[O:20])[NH:15][C:12]2[CH:11]=[N:10][C:9]([C:8]([F:7])([F:16])[F:17])=[CH:14][CH:13]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 27377445-Amino-2-(trifluoromethyl)pyridine

Produkt 1

HCID 11173582Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Pyridine (2.9 mL) was added to a solution of 2-trifluoromethyl-5-aminopyridine (1.95 g) in chloroform (15 mL), the mixture was cooled in ice, and phenyl chloroformate (1.8 mL) was added thereto. The resulting mixture was stirred at room temperature overnight, and the reaction mixture was concentrated under reduced pressure. The residue was washed with isopropyl ether to afford phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (2.16 g).

Aufarbeitung

  1. temperaturethe mixture was cooled in ice
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. washThe residue was washed with isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-5d1832adacc84cc5a9b528ac0e14cb03
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796272B2

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