Methanol → 3-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile

HRID 240306

Reaktionsgleichung

Reaktionsgleichung von HRID 240306
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[CH3:19][OH:20]>>[CH3:19][O:20][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

Komponenten

3

Edukt 2

HCID 887MethanolHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile

Produkt 1

HCID 160653533-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrileAusbeute 126,5 %

Versuchsvorschrift

To a suspension of 1 (1.10 g, 4.7 mmol) in MeOH (47 ml) sodium (110 mg) was added and the mixture was stirred at room temperature for 16 hours. The precipitate was filtered, washed with EtOH and dried under vacuum, yielding 3 (1.03 g, 93%) as yellow-green solid.

Aufarbeitung

  1. additionwas added
  2. filtrationThe precipitate was filtered
  3. washwashed with EtOH
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b40012b19977406f87d5a10b4b6e4989
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648076B2

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