Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 240371

Reaktionsgleichung

Reaktionsgleichung von HRID 240371
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86680841Methyl 5-methyl-2-(pyridin-4-yl)benzoate

Produkt 1

HCID 866808425-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained solid was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e51704f3495d47bdb5219c94a8b48ddf
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648079B2

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